VIP and lissencephaly spectrum disorders: Exocrine pancreatic insufficiency has been described in 2 previous cases7,9,26; however, the diarrhea did not abate with either pancreatic enzyme replacement or total parenteral nutrition with bowel rest.7 Similar findings have been observed in a 2-year-old with X-linked lissencephaly with abnormal genitalia.10 In this case, vasoactive intestinal peptide was normal, and the administration of octreotide was effective in relieving the diarrhea.