As an example, fish oil, which has among its effects metalloproteinase inhibiting properties, has shown benefit as reported in the literature.10, , , , , , -17 However, the stromal biology of cancers is complex and care in manipulating the tumor stroma is needed as cancer stage, patient selection, and possibly proper timing with chemotherapy may make a polar difference in prognosis.18 As pancreatic carcinosarcomas are rare, no known reports have evaluated for CD10 positivity or mentioned use of any metalloproteinase inhibiting substances, which will need further study. This evidence concerns the gene MME and neoplasm.