We, therefore, constructed a targeted geneexpression network for SIR-2.1 and noted that histones (his-13), heat shockproteins (hsp-16.41, hsp-70), serpentine receptors (srh-112, srv-19,srv-22, srx-76, and str-257), transmembrane proteins (pgp-1,str-257, unc-93, mboa-4, and R13G10.4), and proteins related tometabolism and metabolic disease (comt-4, ugt-13, F16G10.14, acdh-1, ugt-63, asah-1,cyp-25A1, and oac-5) were enriched in the network. Here, CD44 is linked to metabolic disease.