Moreover, ZBP89 facilitates the recruitment of HDAC3 to the promoter of CDKN2A to restrain cellular senescence, facilitating lung cancer cell proliferation.94 Recently, it has been demonstrated that ZBP89 regulates the β-catenin pathway, supporting the hypothesis that ZBP89 is involved in cancer metastasis. The gene discussed is ZNF148; the disease is lung carcinoma.