For example, GLIS3 (C2H2-type, transcription factor), a member of Kruppel-like Zinc-Finger proteins, is highly expressed in human pancreatic β-cells, and mutations in the GLIS3 gene have been identified in neonatal diabetes and congenital hypothyroidism (NDH).137 A human GLIS3 mutation that results in a truncated protein at its C-terminal domain has been identified, but the specific mechanism by which this mutation leads to the development of NDH has not been investigated to date. The gene discussed is ZNF300; the disease is neonatal diabetes mellitus with congenital hypothyroidism.