For example, GLIS3 (C2H2-type, transcription factor), a member of Kruppel-like Zinc-Finger proteins, is highly expressed in human pancreatic β-cells, and mutations in the GLIS3 gene have been identified in neonatal diabetes and congenital hypothyroidism (NDH).137 A human GLIS3 mutation that results in a truncated protein at its C-terminal domain has been identified, but the specific mechanism by which this mutation leads to the development of NDH has not been investigated to date. Here, GLIS3 is linked to congenital hypothyroidism.