TP53 and neoplasm: Second, MDM2 interacts with p53 to prevent the binding of p53 to its target genes, which mediate the tumour suppressor function of p53.97–99 Third, MDM2 binds to the N-terminus of p53, promoting the translocation of p53 into the cytoplasm and therefore blocking the activation of p53 target genes (Figure 3f).100–102 The importance of MDM2 in tumorigenesis is also provided by overexpression experiments.