ZNF746 and Parkinson disease: Recently, a novel role for ZNF746 (C2H2-type, not transcription factor), also known as Parkin Interacting Substrate (PARIS), has been identified in the pathogenesis of Parkinson’s disease (PD).132 Human ZNF746 is protein that contains C2HC and C2H2-type zinc-finger domains at the C-terminus.