First, it may act as autonomous transcription factor by regulating the expression of MMP387 (Matrix Metallopeptidase 3) (Figure 3e) a protein involved in tumour development and metastasis.88,89 Second, ZBP89 inhibits ODC (Ornithine Decarboxylase)90 and Vimentin91 expression through recruitment of HDAC1 to the promoter of these genes92,93 (Figure 3e). This evidence concerns the gene ODC1 and neoplasm.