Interestingly, these genes are induced during cardiac hypertrophy.143 In addition, expression of several other proteins, including Na+/Ca2+-exchanger, acetylcholine receptor-M2, cardiac-restricted ankyrin repeat protein (CARP), and adenosine receptor-A1 and carnitine palmitoyltransferase-1β, is regulated by GATA4.144,145 These findings suggest that GATA transcription factors could be an attractive therapeutic target for the treatment of cardiovascular diseases. The gene discussed is GATA4; the disease is cardiac hypertrophy.