Furthermore, there is a strong relationship between obesity and inflammation(13), since hyperadiposity produces adipokines, such as leptin, adiponectin and resistin, as well as proinflammatory cytokines such as IL-6, TNF-α and plasminogen activator inhibitor type 1, which are all involved in proinflammatory and prothrombotic responses(14). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.