However, fluorescent in situ hybridization (FISH) established that the full length C22orf2 gene follows BCR sequences in CML myeloid progenitors, and relocates to the derivative chromosome 9 (der(9q)) in patients with the typical translocation t [9, 22] [q34;q11] or to the second fusion gene in patients with variant translocations [18, 19]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.