CBY1 and chronic myelogenous leukemia, BCR-ABL1 positive: We found that enhanced recruitment of DNMT1 at the C22orf2 promoter is a component of CBY1 down-modulation in CML hematopoietic progenitors and LSC, hence suggesting the putative advantage of DNA-demethylating drugs, such as 5-Aza-CdR (also referred to as decitabine), in the disease therapy [30].