Due to the relative proximity of C22orf2 [22q13.1] to the breakpoint cluster region on BCR (22q11) we first investigated whether C22orf2 haplo-insufficiency, originated by deletion(s) downstream of BCR sequences as a result of the t(9, 22) translocation, was correlated with CML prognosis [22]. Here, CBY1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.