Upregulation of C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-balactosyltransferase, 1)-mediated O-glycosylation was required to mediate galectin-4 binding and RTK activation, suggesting that concomitant changes in O-glycosylation and galectin-4 overexpression in PCa cells induced EMT-like phenotypes and metastasis [83]. This evidence concerns the gene LGALS4 and posterior cortical atrophy.