Additionally, PCSCs from both prostate draining lymph nodes and mPIN lesions expressed CXCR4 (C-X-C chemokine receptor type 4), which was essential for PCSC-mediated tumor metastasis, and migrated in response to CXCL12 (chemokine stromal cell derived factor-1 (SDF-1)), which was overexpressed specifically in the lymph nodes upon mPIN development, suggesting a homing strategy induced in PCSCs [80]. This evidence concerns the gene CXCR4 and neoplasm.