Finally, autocrine cholinergic signaling promoted PCa growth and castration resistance - endogenous acetylcholine activated CHRM3 (cholinergic muscarinic receptor 3) in PCa cells, promoted CaM/CaMKK–mediated phosphorylation of Akt, induced PCa cell migration by regulating EMT, and conferred castration resistance [86]. The gene discussed is CAMKK2; the disease is posterior cortical atrophy.