TWIST1 facilitated PCa metastasis by regulating HOXA9 (homeobox A9) expression via cooperating with WDR5 (WD repeat-containing protein 5), a scaffolding protein, and lncRNA Hottip/HOTTIP, a long noncoding RNA, to increase H3K4 trimethylation at HOXA9 promoter leading to invasion [59]. Here, HOXA9 is linked to posterior cortical atrophy.