Advanced PCa cells express RAGE (the receptor for advanced glycation endproducts), a transmembrane receptor of the immunoglobulin super family, on their cell surface, which bound PR3 (proteinase 3), a serine protease present in inflammatory neutrophils and hematopoietic cells within the bone marrow microenvironment, thus mediating homing of PCa cells to the bone marrow [101]. Here, NRP1 is linked to posterior cortical atrophy.