IL6 and posterior cortical atrophy: Finally, increased TBX2 (T-box transcription factor 2) expression activated an invasive and metastatic behavior in PCa cells, promoting bone metastasis and growth in the bone microenvironment that was mediated by the canonical WNT (WNT3A) promoter and its downstream effectors, MMP9 (matrix metallopeptidase 9), MMP2, and IL-6 (interleukin-6) [39].