To date, no case-control studies have been conducted to assess the association of genetic variations in the lipid regulatory pathway genes FBXW7 and SREBPs with CAD in different ethnic groups.Thus, the current study was designed to explore the possible correlation between single nucleotide polymorphisms (SNPs) in the lipid regulatory pathway genes FBXW7 and SREBPs (rs9902941 in SREBP-1, rs7288536 in SREBP-2 and rs10033601 in FBXW7) with CAD among Han Chinese and Uygur Chinese populations in Xinjiang, China. This evidence concerns the gene SREBF2 and coronary artery disorder.