For instance, Gao et al. discovered that a lncRNA, RoR, was capable of binding to miR-145 for competitive regulation of Nanog expression in pancreatic cancer [29], while the lncRNA HOTAIR was shown to act as a ceRNA for miR-217 to facilitate HIF-1α expression and upregulation of AXL in renal cell carcinoma [30]. This evidence concerns the gene AXL and hereditary clear cell renal cell carcinoma.