The present study suggests an essential role for the CRNDE-miR-136-5p-Bcl-2/Wnt2 regulatory pathway in the malignant progression of glioma, by showing that CRNDE competitively binds miR-136-5p and thus indirectly inhibits the post-transcriptional expression of Bcl-2 and Wnt2, whose upregulation is known to be associated with glioma malignancy. This evidence concerns the gene WNT2 and central nervous system cancer.