AKT1 and glioma: In summary, although glioma cell growth and invasion has been previously linked to CRNDE-mediated modulation of mTOR signaling [15, 26], we expanded this knowledge through experiments that indicated that CRNDE could increase, via repression of miR-136-5p, the levels of Bcl-2 and Wnt2, two downstream effectors of the PI3K/AKT/mTOR signaling pathway, thus contributing to the malignant characteristics of glioma (Figure 8).