Given that the ERK and AKT signaling are important for the growth, angiogenesis and metastasis of cancers the inhibition of lung cancer growth, metastasis and angiogenesis by miR-370 over-expression may be also mediated by miR-370 attenuating the EGFR expression and down-stream ERK and AKT signaling in vivo. This evidence concerns the gene AKT1 and lung cancer.