Additionally, among cancer patients, hormone receptor positive (H = 3.6 ± 0.8) samples had higher Shannon diversity relative to hormone receptor negative (H = 2.9 ± 0.6) samples (p = 0.03) [Figure 1D], but this only trended towards significance in the observed OTU count: hormone receptor positive vs. negative (N = 21.2 ± 6.4 vs. 16.5 ± 4.4, p = 0.08). This evidence concerns the gene NR4A1 and cancer.