Similarly, decreased NTRK2 expression in high compared to low grade astrocytoma [41], decreased ST3GAL6 expression in liver tumours [42], and increased AKR1C3 expression in 1q19p co-deleted glioma compared to other glioma subtypes [43] support a low-malignant function, although other studies on NTRK2 [44, 45], AKR1C3 [46, 47], and ST3GAL6 [48] are inconsistent. Here, AKR1C3 is linked to central nervous system cancer.