IGF1 rs6218 G allele (OR=1.57, 95%CI=1.14-2.12), rs35767 T allele (OR=1.39, 95%CI=1.03-1.88) and rs5742612 C allele (OR=1.39, 95%CI=1.02-1.91) may obviously enhance the risk of T2DM development. This evidence concerns the gene IGF1 and type 2 diabetes mellitus.