Univariate analysis were found significant relationships between response and smoking history (p < 0.001), tumour site (p = 0.05), clinical stage (p < 0.001), NLR (p = 0.003), PLR (p = 0.005), CNP (p < 0.001), and Hb level (p < 0.001) (Table 2). This evidence concerns the gene CNP and neoplasm.