In cholestasis, to compensate, the main influx transporters of the basolateral membrane of hepatocytes, including sodium/bile acid and sulfated solute cotransporter1 (Slc10a1) and organic anion transporter (Slco1a1), are down-regulated, whereas main efflux transporters of the basolateral membrane of hepatocytes, including Mrp3, Mrp4 and Ostα/β, are up-regulated to reduce or accelerate the uptake or secretion of bile acids and other organic anions [33]. This evidence concerns the gene ABCC4 and cholestasis.