These findings as well as our results indicate that DUXAP8 may be an important oncogenic lncRNA in RCC metastasis through interacting with histone modification enzymes and repressing some important cancer cells metastasis regulators expression, and DUXAP8 could be an useful prognostic marker and survival predictor for RCC and other cancers patients. This evidence concerns the gene DUXAP8 and renal cell carcinoma.