In the past, most studies on FGFs in melanoma have concentrated on FGF2 [28, 32] and while - in addition to FGF2 - overexpression of FGF5 mRNA was noted in some melanoma cell lines more than two decades ago [24], FGF5 protein expression in melanoma tissue and its impact on melanoma growth were never investigated. The gene discussed is FGF2; the disease is melanoma.