An extensive genomic analysis of somatic copy number amplification (SCNA) in more than 3,000 cancer specimens representing 26 histological type, identified MCL1 is enriched among regions of focal SCNA, and MCL1 amplification is found in more than 10% of cancers across multiple tissue types, including breast cancer, lung adenocarcinoma and melanoma [13]. This evidence concerns the gene MCL1 and melanoma.