MCL1 and esophageal squamous cell carcinoma: Figure 1 illustrates representative FISH signal patterns of select MCL1 anomalies including high MCL1 gain (>5.0 average MCL1 gene copies/nucleus), low MCL1 gain (2.5 to 5 average MCL1 copies/nucleus), and normal or loss of MCL1. Table 1 shows the relationships between MCL1 status and the clinicopathological parameters in ESCC.