ISL1 and hepatocellular carcinoma: In view of the suppressive role of miR-31 on ɑ2δ1+ TICs by targeting ISL1 directly, we measured the expression of miR-31 and ISL1 in ɑ2δ1+ HCC TICs and ɑ2δ1− non-TICs sorted from HCC cell lines Huh7 and PLC/PRF/5.