ISL1 and hepatocellular carcinoma: As shown in Figure 5A, the expression of miR-31 was downregulated remarkably in ɑ2δ1+ HCC TICs compared with their negative counterparts, while the expression of its target gene ISL1 was upregulated in ɑ2δ1+ HCC TICs compared with respective ɑ2δ1− subsets (Figure 5B).