Given that leukemia-initiating cells or leukemia stem cells (LSCs) in murine model of MLL-AF9+ AML are Kit+CD11b+Gr1+ cells [13, 30], our finding suggests that Necdin-deficiency may decrease the number of LICs in MLL-AF9-induced leukemia. This evidence concerns the gene KMT2A and acute myeloid leukemia.