Given that Necdin maintains HSC quiescence [20–21] and GMPs (Lin−Sca1−IL7R−Kit+FcγRII/IIIhighCD34high) are leukemia-initiating cells (LICs) in MLL-AF9 induced leukemia [13], we examined the impact of Necdin deficiency on the quiescent state of GMPs using Ki67 and DAPI staining. The gene discussed is MKI67; the disease is leukemia.