L1CAM and ovarian carcinoma: Zecchini et al., describe a dual role for L1CAM, as L1CAM supported cell-cell adhesion and enhanced apoptosis in nontransformed ovarian epithelial cells, while it inhibited cell-cell adhesion and apoptosis and promoted malignancy-related properties, such as cell proliferation, invasion, and transendothelial migration in ovarian carcinoma cells [8].