Thirty-two patients with active RA became stable after comprehensive treatment with analgesic anti-inflammatory and antirheumatic drugs for 6 months, reducing the expression level of TIPE2 in peripheral blood to 2−ΔΔCt (3.53 ± 0.89; ANOVA, F = 116.12, P < 0.001). Here, TIPE2 is linked to rheumatoid arthritis.