The PIK3CA c.3140A>G (p.H1047R) and c.1633G>A (p.E545K) somatic mutations are commonly found in colorectal carcinoma, and were present in the colon cancer cells (HCT15 and HCT116, respectively) included in the published studies [36, 37]. The gene discussed is PIK3CA; the disease is malignant colon neoplasm.