Dual inhibition of COX-2 and sEH by either a combination of selective inhibitors of each enzyme or a COX-2/sEH dual inhibitor PTUPB as a single agent suppress primary tumor growth and metastasis by inhibiting tumor angiogenesis with the mechanisms of reduction of VEGF and PGE2, stabilization of EETs and inhibition of endothelial cell proliferation [18]. This evidence concerns the gene EPHX2 and neoplasm.