In contrast, some researcher observed that hCG alone was able to induce follicular growth instead of FSH [8], meanwhile, a beneficial effect of adding low-dose hCG to FSH was reported in patients with hypogonadotropic hypogonadism [9], polycystic ovarian syndrome [10] or poor ovarian response [11]. This evidence concerns the gene BRD2 and hypogonadotropic hypogonadism.