As shown in Table 1, there were significant differences between HGDNs and WD-SHCCs in multiple preoperative clinicopathological parameters, including tumor sizes, platelets (PLT), prothrombin time (PT), albumin/globulin (A/G), alanine aminotransferase (ALT), α-fetal protein (AFP), carbohydrate antigen19-9 (CA19-9), cirrhosis, SC, DR, SA and IPA. The gene discussed is ALB; the disease is Wilson disease.