ANXA5 and familial pancreatic carcinoma: To determine if panbinostat can enhance killing of tumor cells by LMB-100, we treated the pancreatic cancer cell line KLM1 with 5 ng/ml LMB-100 alone, 20 nM panbinostat alone or both for 72 hours; the cells were then stained with 7-AAD and Annexin V to measure the percentage of dead and apoptotic cells by flow cytometry.