CD274 and non-small cell lung carcinoma: The treatment landscape of NSCLC has transformed with the approval of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) blockade agents such as nivolumab, pembrolizumab, atezolizumab, and pembrolizumab in patients with ≥50% PD-L1 expression as a front line of therapy [2–7].