TERT and acute lymphoblastic leukemia: Although the outstanding clinical success achieved by CAR-mediated immunotherapy in contrasting B-ALL progression has comprehensibly attracted the interest of scientific community for the development and improvement of this type of engineered T-cell therapy, the idea of redirecting T-lymphocytes with high affinity TCR selective for universal tumour-associated antigens, such as TERT, may open new avenues on the clinical procedure.