A spontaneous immune response against TERT was reported in different tumour settings and anti-TERT specific CD8+T cells were detected, with a higher frequency, in the blood of patients affected by chronic lymphocytic leukemia (B-CLL), as well as breast, lung and colorectal cancers, compared to healthy donors (HD) [38–42]. Here, CD8A is linked to B-cell chronic lymphocytic leukemia.