Moreover, the E693Δ deletion has been shown to be antiamyloidogenic and neither extracellular amyloid plaques nor tau tangles are formed in transgenic mice expressing APP E693Δ, suggesting that not all currently available models are successful in exhibiting AD-like pathology, and so not all are valid for the generation of AD iPSC lines [40, 41]. The gene discussed is MAPT; the disease is Alzheimer disease.