Since Down’s Syndrome patients have a predilection to develop AD, they hypothesised that iPSC-derived cortical neurons taken from Down’s Syndrome patients could be used to model early onset FAD as they harboured three copies of APP. It has also been shown that increased APP expression in mice and humans results in amyloid plaques, early onset dementia and other neuropathological hallmarks [36, 49]. Here, APP is linked to Down syndrome.