TRIM63 and chronic obstructive pulmonary disease: The genetic deletion of these “atrogenes” attenuates muscle atrophy under various conditions, for example, sepsis-induced atrophy, ventilation-induced atrophy hydrogen peroxide-induced atrophy and so on [25, 26], and increased expression of MuRF1 and atrogin-1 has been documented in the quadriceps muscle during COPD [27].