CELF1 and esophageal cancer: However, other studies demonstrated that miR-214-3p was significantly downregulated in two esophageal squamous cancer cell lines compared with esophageal epithelial cells [19]. Further investigations pointed out that downregulation of miR-214-3p suppressed chemoresistance in esophageal cancer cells by targeting both survivin and CUG-BP1 [20].