<h4>Background</h4>B-cell lymphomas harboring the 8q24/<i>MYC</i> plus 18q21/<i>BCL2</i> translocations are now referred to as high grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> and/or <i>BCL6</i> rearrangements (HGBL-MBR). This evidence concerns the gene BCL2 and B-cell non-Hodgkin lymphoma.