A similar phenomenon was also observed in vivo in the striata of HD mice (HdhQ140/Q7) compared to WT controls (HdhQ7/Q7) at the age of 6-8 months (Figure 3D, right), in line with previous reports in human brain tissues, where the HIPK3 expression is ∼33% higher in HD patients versus controls40. The gene discussed is HIPK3; the disease is Huntington disease.