In mouse striatal HD cells (STHdhQ7/Q111) but not WT cells (STHdhQ7/Q7), Htt mRNA was significantly reduced by knocking down Mapk11 (Figure 5A, statistics on right), and this showed a significant positive correlation with Mapk11 mRNA levels (Figure 5A, statistics on top). The gene discussed is HTT; the disease is Huntington disease.