In the HD mice (Supplementary information, Table S2, right parts), Mapk11+/− and Mapk11−/− showed overwhelmingly more rescues (green) than exacerbations (orange), an outcome highly unlikely to have resulted from random noise (Mapk11+/−: 21 rescues versus 5 exacerbations, P = 0.0009; Mapk11−/−: 22 rescues versus 4 exacerbations, P = 0.00009; Mapk11+/− & Mapk11−/− together: 43 rescues versus 9 exacerbations, P = 5E−7). This evidence concerns the gene MAPK11 and Huntington disease.