GRN and kidney injury: Interestingly, a reduction in PGRN expression has been observed in an acute kidney injury mouse model after ischemia/reperfusion and in the cerebrospinal fluid of patients with subarachnoid hemorrhage (Zhou, Tang, et al., 2015; Zhou, Xie, et al., 2015), suggesting that PGRN expression in inflammatory disorders may be, in part, dependent on the particular disease model.