Interestingly, we also found the expression levels of miR‐34b‐5p and PGRN was both up‐regulated in the lungs from the mice with ALI at 24 hr, and we hypothesized that PGRN was not only regulated by miR‐34b‐5p but also modulated by various factors, such as TMEM106B and IL‐6 (Finch et al., 2011; Liu, Zhang, et al., 2016), indicating that other mechanisms may involve in the regulation of PGRN expression during ALI. The gene discussed is GRN; the disease is acute respiratory distress syndrome.