In total, we identified 28 different variants in nine OI genes, including 10 COL1A1, five COL1A2, three BMP1, three FKBP10, two TMEM38B, two P3H1, one CRTAP, one SERPINF1, and one SERPINH1 (Table 1). The gene discussed is CRTAP; the disease is osteogenesis imperfecta.