In up-regulated genes, the maximum similarity was between MArrest and teratospermia, with 12 common genes among 880 genes (0.014%) (MLC1, LSP1, GRK5, BCORL1, DICER1, CCNG1, RBMS3, DCN, RPL6, ADAMTS5, HNRNPU and PDE1A). The gene discussed is PDE1A; the disease is Abnormal sperm morphology.