As shown in Table 1, the higher number of common up-regulated genes was found between Etv5 KD and Pou3f1 KD, with 53 genes, Bcl6b KD and Etv5 KD, with 19 genes, Bcl6b KD and Pou3f1 KD, with 14 genes, MArrest and teratospermia, with 12 genes, and MArrest and Ing2 KO, with nine common genes. The gene discussed is POU3F1; the disease is Abnormal sperm morphology.