However, biopsies from PNPLA3 variant carriers showed higher degree of steatosis (p = 0.022, Fig. 3), DR (p = 0.044, Fig. 4A), IH (p = 0.027), and a higher number of αSMA+ portal/septal MFs (p = 0.040, Fig. 4B) and portal S100A9+ macrophages (p = 0.039, Fig. 4C) when compared with WT patients (Table 3). Here, PNPLA3 is linked to steatosis.