Interestingly, when patients with MetS were separately considered (N = 32), biopsies from PNPLA3 variant carriers (N = 23) still showed significantly higher degree of steatosis (p < 0.05), DR (p < 0.05), and portal inflammation (p < 0.05) when compared with WT patients (N = 9). The gene discussed is PNPLA3; the disease is steatosis.