Serum Nox2 was correlated with NAS (r = 0.59; p < 0.001), DR (r = 0.36; p < 0.05), the number of αSMA+ pericentral HSCs (r = 0.40; p < 0.05) and αSMA+ portal/septal MFs (r = 0.51; p = 0.001), the degree of steatosis (r = 0.37; p < 0.05) and lobular inflammation (r = 0.38; p < 0.05). The gene discussed is CYBB; the disease is steatosis.