PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Moreover, PNPLA3 variants have been associated with a worse histological depict in NAFLD6; however, no studies investigated the potential influence of PNPLA3 I148M variant in the development of specific histological pattern and in the intricate cross-talks between different cellular compartments activated by the regenerative response to liver damage in NAFLD.