Strikingly, however, deletion of HIF-1α in NK cells and a reduction in sVEGFR1 levels (Supplementary Fig. 7a) in VEGF null tumours rescued VEGFR2 signalling (Supplementary Fig. 7b) and tumour growth (Fig. 7a) along with restored angiogenesis (Fig. 7e) and alleviated hypoxia (Fig. 7f). This evidence concerns the gene VEGFA and neoplasm.