Again, tumours that expressed VEGF grew significantly smaller in HIF-1α KO mice (Fig. 7a) showed lower levels of sVEGFR1 (Supplementary Fig. 7a) and enhanced VEGFR2 signalling (Supplementary Fig. 7b), resulting in non-productive angiogenesis, characterised by pericyte loss (Fig. 7b, e), increased hypoxia (Fig. 7c, f) and tumour cell death (Fig. 7d, g). Here, KDR is linked to neoplasm.