In humans, 10 of the 16 signature genes were upregulated in CCR6+ myelin-reactive memory CD4+ T cells in patients with MS although these cells also displayed elevated levels of IL1019, while 12 genes were upregulated in TH1/17-enriched CCR7loCCR6+CCR4loCXCR3hi memory CD4+ T cells in healthy donors compared to TH17-enriched CCR7loCCR6+CCR4hiCXCR3lo cells33 (Supplementary Data 2). Here, CCR6 is linked to myeloid sarcoma.