Given the facilitating role of STAT3 in TH17 differentiation and the anti-inflammatory function of IL-10, these results together with the altered expression of CXCR3, IFNG, CCL3, CLL4, GZMB, IL10, STAT3, and STAT5A in MS (Fig. 6) are consistent with an important role for TH17 cells in MS. The gene discussed is STAT5A; the disease is myeloid sarcoma.