The low expression of IL10 in CXCR3hi TH1/17 cells in MS suggests these pro-inflammatory cells may more readily migrate to central nervous system (CNS) since CXCL10 (IP-10), a ligand for CXCR3, is increased in the inflamed CNS in MS41–44. The gene discussed is CXCR3; the disease is myeloid sarcoma.