As a second approach, we performed western blot analysis of SKOV3 ovarian cancer cells after knockdown of DNM3OS. There were elevated protein levels of the epithelial marker E-CADHERIN, and reduced levels of the mesenchymal protein N-CADHERIN in the DNM3OS knockdown cells compared to control (Fig. 6d). The gene discussed is CDH1; the disease is ovarian carcinoma.