Nevertheless, C. albicans mutants that affect homologous recombination or nonhomologous end-joining (NHEJ) repair of DNA DSBs, such as LIG4 (which is the structural and functional homolog of both yeast and human ligase IV, involved in NHEJ) and RAD52, resulted in the attenuation of virulence in a murine model of candidiasis (Andaluz et al. 2001; Chauhan et al. 2005). This evidence concerns the gene RAD52 and candidiasis.