CACNA1C and heart failure: 2017) and has suggested that the scaffolding protein caveolin‐3 is involved in the t‐tubular localization of proteins, including Cav1.2, and thus ICa (Bryant et al. 2014). Since caveolin‐3 binds to cholesterol, this implies that t‐tubular cholesterol may also be important in protein localization, and redistribution of caveolin‐3 to noncholesterol‐rich membranes in heart failure has been suggested to lead to loss of caveolin‐3 from the t‐tubules (Ratajczak et al. 2003), which could explain the redistribution of ICa away from t‐tubules observed in heart failure (Bryant et al. 2015).