NEK1 and amyotrophic lateral sclerosis: An association analysis for this variant in 1022 familial ALS (fALS) plus 6172 sporadic ALS (sALS) cases compared to 11,732 controls found the allele frequency at this locus to be 0.81% in cases compared to 0.35% in controls (odds ratio [OR] = 1.41, p = 1.2 × 10–7), thus confirming NEK1 as an ALS risk gene.