KMT2A and leukemia: By mapping the HOXA gene cluster using the 5C technique and analyzing the gene cluster using 3D DNA disease-signature predictor, the MLL-fusion protein can be classified as wild-type, and the subtypes of leukemia can be classified according to their different MLL-fusion partners with high accuracy; thus, the MLL-fusion protein can be used as a novel marker, but this has been verified only in cell lines, and a clinical trial is necessary [106].