TCF7 and glioblastoma: Similarly, changes were observed for LEF1, an effector of the Wnt signaling pathway known to be involved in neurogenesis [8] and maintenance of GBM stem-like cell [38, 77, 79], TCF3 and TCF7 that are transcriptional regulators of the Wnt pathway in neural stem cells and ESC [40, 74] and the HES bHLH genes and FOXCs transcription factors implicated in the Notch signaling pathway, which is activated in neural stem cells and GBM stem-like cells [36, 72].