[29, 30] Moreover, the levels of pro-inflammatory cytokines have been reported to be elevated among patients with cirrhosis compared to healthy controls, with elevations of IL-6 found in both compensated and decompensated cirrhosis.[29] Our group and others have previously reported an association between IL-6 and/or CRP and anxiety, depression, poor sleep quality and pain.[9, 31, 32] Our findings thus extend these results by suggesting a potential utility of inflammatory markers in predicting hospitalization. Here, IL6 is linked to major depressive disorder.