TRPV-1 receptors have been demonstrated at alveolar level [33], and although the peripheral C-fibres are thought to be inhibitory, there is evidence for increased expression of neurotrophins distally from bronchoalveolar lavage fluid samples in IPF which have been implicated in adaptive responses within sensory neurones, including fibre phenotype switching, and increased expression and functionality of TRP receptors [5, 8]. Here, BDNF is linked to idiopathic pulmonary fibrosis.