LGR5 and neoplasm: Studies examining the function of LGR5 in CRC cells have produced confusing and contradictory results, with some studies suggestive of a pro-tumourigenic role for LGR5 (Hirsch et al, 2014; Liu et al, 2014; Lin et al, 2015) while others indicate a tumour-suppressive role (de Sousa et al, 2011; Walker et al, 2011; Wu et al, 2014).