S1PR2 has an ability to enhance the expression of plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator receptor (uPAR) through the activation of dual downstream signaling cascades MEK1/2 and Rho-kinase, which are vital for glioblastoma invasiveness. The gene discussed is SERPINE1; the disease is glioblastoma.